Effect of placental restriction and neonatal exendin - 4 treatment on postnatal growth , adult body 1 composition and in vivo glucose metabolism in the sheep 2 3

Effect of placental restriction and neonatal exendin-4 treatment on postnatal growth, adult body 1 composition and in vivo glucose metabolism in the sheep 2 3 Hong Liu, Christopher G Schultz, Miles J De Blasio, Anita M Peura, Gary K Heinemann, 4 Himawan Harryanto, Damien S Hunter, Amy L Wooldridge, Karen L Kind, Lynne C Giles, 5 Rebecca A Simmons, Julie A Owens, Kathryn L Gatford 6 Robinson Research Institute, and School of Paediatrics & Reproductive Health, School of Animal & 7 Veterinary Sciences, School of Population Health, University of Adelaide, Adelaide SA 5005, 8 Australia; Department of Nuclear Medicine, PET & Bone Densitometry, Royal Adelaide Hospital, 9 Adelaide SA 5000, Australia; and Medical School, University of Pennsylvania, USA. 10 MJD, Present address: Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia. 11 Running title: Adult outcomes of neonatal exendin-4 treatment in PR sheep 12 13 Corresponding author: 14 Dr Kathryn L Gatford 15 Robinson Research Institute and School of Paediatrics & Reproductive Health, University of Adelaide 16 SA 5005, Australia 17 18 Phone: +61 8 8313 4158 19 Fax: +61 8 8313 4099 20 E-mail: [email protected] 21 Articles in PresS. Am J Physiol Endocrinol Metab (July 28, 2015). doi:10.1152/ajpendo.00487.2014